Which conditions are associated with localized hyperhidrosis?

Updated: Mar 23, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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Localized hyperhidrosis may also be associated with the following:

  • Gustatory stimuli (associated with Frey syndrome, encephalitis, syringomyelia, diabetic neuropathies, herpes zoster parotitis, and parotid abscess)

  • Eccrine nevus: This may be associated with severe localized hyperhidrosis. [12]

  • Eccrine angiomatous hamartoma: This is a rare, benign malformation characterized by both eccrine and vascular components. [13, 14] It is usually first evident at birth or during early infancy and childhood as a nodule or a plaque, usually solitary, involving acral skin. Although often asymptomatic, it may be associated with focal hyperhidrosis, hypertrichosis, and pain.

  • Peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasma-proliferative disorder, and skin changes (POEMS) syndrome

  • Burning feet syndrome

  • Spinal cord tumors: Rarely, hyperhidrosis may be an initial symptom. [15]

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