Which conditions are associated with hyperhidrosis?

Updated: Mar 23, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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Generalized hyperhidrosis may be secondary to numerous conditions including the following:

  • Neurologic or neoplastic diseases: Contralateral hyperhidrosis in the left ophthalmic trigeminal division was documented on the forehead after a lateral medullary infarction. [5] Paroxysmal sympathetic hyperactivity after a spontaneous intracerebral hemorrhage may also produce hyperhidrosis. [6]

  • Spontaneous periodic hypothermia and hyperhidrosis: This is postulated to be a rare cerebral neurotransmitter disorder. [7, 8]

  • Metabolic disorders or processes (eg, thyrotoxicosis, diabetes mellitus, hypoglycemia, gout, pheochromocytoma, menopause)

  • Febrile illnesses

  • Medications: Use of medications may affect one or more components of human thermoregulation and induce hyperhidrosis. Agents such as propranolol, physostigmine, pilocarpine, tricyclic antidepressants, and serotonin reuptake inhibitors have been implicated. Efavirenz was recently described to induce excessive nocturnal sweating that resolved after dose reduction. [9]

  • Hodgkin disease or tuberculosis (in nocturnal hyperhidrosis)

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