Which medications in the drug class Antiandrogens are used in the treatment of Hidradenitis Suppurativa?

Updated: Aug 30, 2019
  • Author: Marina Jovanovic, MD, PhD; Chief Editor: William D James, MD  more...
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Answer

Antiandrogens

Combined treatment with the antiandrogen cyproterone acetate and ethinyl oestradiol has been shown to be of benefit to women with long-standing hidradenitis suppurativa.

Spironolactone (Aldactone)

Spironolactone is an aldosterone antagonist that inhibits ovarian and adrenal production of androgens. It competes with dihydrotestosterone binding at hormone receptor sites on hair follicle cells. It also reduces 17-alpha-hydroxylase activity, lowering plasma levels of testosterone and androstenedione.


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