Which medications in the drug class Immunosuppressants are used in the treatment of Hidradenitis Suppurativa?

Updated: Aug 30, 2019
  • Author: Marina Jovanovic, MD, PhD; Chief Editor: William D James, MD  more...
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Answer

Immunosuppressants

Because of the concurrent presentation of hidradenitis suppurativa and Crohn disease, as well as the morphological and histological similarities, these two conditions may share the same pathogenesis, namely excess tumor necrosis factor-alpha (TNF-alpha) production.

Adalimumab (Humira)

Adalimumab is a recombinant human anti-TNF-alpha IgG1 monoclonal antibody; it blocks the inflammatory activity of TNF-alpha; it specifically binds to TNF-alpha and blocks its interaction with p55 and p75 cell surface TNF receptors; it also lyses surface TNF-expressing cells in vitro and modulates biologic responses responsible for leukocyte migration.

Infliximab (Remicade)

Infliximab inhibits TNF-alpha activity and triggers complement-mediated lysis of TNF-alpha–expressing cells in vitro. It is a monoclonal chimeric antibody made from human constant and mouse variable regions of IgG, with binding specificity for human TNF-alpha. It binds to inactive TNF-alpha and can bind specifically to both membrane-bound and soluble TNF-alpha. Infliximab binds to inactive TNF-alpha monomers, preventing their association into active trimers. It is used to treat severe inflammatory diseases that do not respond to systemic corticosteroids or immunosuppressants.


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