Which medications in the drug class Estrogen Derivatives are used in the treatment of Hidradenitis Suppurativa?

Updated: Aug 30, 2019
  • Author: Marina Jovanovic, MD, PhD; Chief Editor: William D James, MD  more...
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Answer

Estrogen Derivatives

Treatment with the antiandrogen cyproterone acetate in combination with estrogen ethinyl estradiol and ethinyl estradiol in combination with the low-dose progestin norgestrel may significantly improve disease activity, especially in patients with mild forms of hidradenitis suppurativa, but many conditions do not respond to these treatments. The therapy is mainly indicated for female patients with menstrual abnormalities, signs of hyperandrogenism, or upper normal or high serum levels of dehydroepiandrosterone, androstenedione, and/or sexual hormone-binding protein.

Norgestrel/ethinyl estradiol (Cryselle 28, Elinest, Lo-orgestrel, Orgestrel)

Norgestrel/ethinyl estradiol reduces secretion of luteinizing hormone and follicle-stimulating hormone from the pituitary gland by decreasing the amount of gonadotropin-releasing hormones.


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