Which medications in the drug class 5-Alpha-Reductase Inhibitors are used in the treatment of Hidradenitis Suppurativa?

Updated: Aug 30, 2019
  • Author: Marina Jovanovic, MD, PhD; Chief Editor: William D James, MD  more...
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Answer

5-Alpha-Reductase Inhibitors

Agents in this class decrease dihydrotestosterone serum levels and may be beneficial to hidradenitis suppurativa.

Finasteride (Proscar)

Finasteride inhibits steroid 5alpha-reductase, which converts testosterone into 5alpha-dihydrotestosterone (DHT), causing serum DHT levels to decrease. All skin tissue predominantly contains type 1 isoenzyme, and the genital region contains type 2. Finasteride has been effective in treating hirsutism. Finasteride might be a suitable additive therapy for refractory female hidradenitis suppurativa cases.


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