What evidence supports the theory of an androgen etiology of hidradenitis suppurativa (HS)?

Updated: Aug 30, 2019
  • Author: Marina Jovanovic, MD, PhD; Chief Editor: William D James, MD  more...
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Answer

The following evidence supports the association of androgens and hidradenitis suppurativa: the disease is rarely present until after puberty begins, [44] Hidradenitis suppurativa is not present in eunuchs or eunuchoids, and hidradenitis suppurativa may occur as the presenting feature of premature adrenarche. [45] Also, antiandrogen therapy is of some benefit in patients with hidradenitis suppurativa. [46]

The relationship between hidradenitis suppurativa and hyperandrogenism is largely based on the finding that the free androgen index is increased due to a low level of sex hormone–binding globulin (SHBG). SHBG is now believed to be regulated by factors that influence body weight. [42]


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