Which clinical history findings are characteristic of acne conglobata (AC)?

Updated: Apr 06, 2020
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Both acne conglobata and acne fulminans (AF) can be induced by anabolic-androgenic steroid abuse. [10] Although this probably represents only a small minority of cases, one should recognize bodybuilding acne, address the substance abuse, and warn patients about other potential hazards.

Acne conglobata can be associated with hidradenitis suppurativa. Note that hidradenitis suppurativa occurs more frequently in patients with mild acne than in other patients. [11] The hidradenitis may extensively involve the perineal and gluteal regions. [12]  Sex and body mass index may influence sites of involvement. [13]

The list of possible associations of pyoderma gangrenosum must include acne conglobata. [14]

The association of acne conglobata and arthritis is rare, and has been reported only in single case reports in the literature, [15, 16, 17] although musculoskeletal syndrome (ie, myalgia, arthralgia, arthritis, hyperostosis) developed in some patients with severe acne (acne conglobata and acne fulminans). [18]

Pyoderma gangrenosum, acne conglobata, and immunoglobulin A gammopathy has been observed. [19]

Spondyloarthritis associated with acne conglobata, hidradenitis suppurativa, and dissecting cellulitis of the scalp has been reported. [20]

Renal amyloidosis may accompany acne conglobata. [21]

Acne conglobata and hidradenitis suppurativa may have a familial tendency; however, no significant relationship in the antigen patterns of patients with acne conglobata was observed.

The SAPHO syndrome of synovitis, acne conglobata, pustulosis, hyperostosis, and osteitis is rare, but should not be overlooked. [5, 22, 23] Affected individuals may have difficulty walking, owing to pain, weakness, and weight loss.

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