Which medications in the drug class Nonsteroidal Anti-inflammatory Drugs (NSAIDs) are used in the treatment of Acneiform Eruptions?

Updated: Jul 29, 2019
  • Author: Julianne H Kuflik, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Because the etiology and the pathogenesis of eosinophilic pustular folliculitis have not been fully elucidated, no established treatment schemes exist. A number of options have been tried with various results; however, no controlled treatment trials have been performed for this condition. Oral indomethacin consistently appears to be most beneficial, at least in the classic form of the disease.

Indomethacin (Indocin)

Indomethacin is a potent inhibitor of cyclooxygenase, which may decrease the local production of arachidonic acid derived chemotactic factors for eosinophils present in sebum (eg, 12-L-hydroxy-5,8,10-heptadecatrienoic acid and/or prostaglandin).


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