Which medications in the drug class Antibiotics, Other are used in the treatment of Acneiform Eruptions?

Updated: Jul 29, 2019
  • Author: Julianne H Kuflik, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Antibiotics, Other

Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of this clinical setting. Antibiotic treatments for rosacea include tetracyclines and metronidazole. Dapsone is used in the treatment of eosinophilic pustular folliculitis.

Dapsone (Aczone)

Dapsone prevents bacterial use of para-aminobenzoic acid (PABA) for folic acid synthesis by acting as a competitive inhibitor.

Tetracycline

Tetracycline inhibits bacterial protein synthesis by binding with 30S and, possibly, 50S ribosomal subunit(s). Tetracycline has anti-inflammatory activity. It can be administered at 250-500 mg orally twice daily.

Doxycycline (Doryx, Adoxa, Monodox, Vibramycin)

Doxycycline is a broad-spectrum antibiotic with excellent gram positive cover, including most resistant staph organisms. It inhibits protein synthesis and, thus, bacterial growth by binding to 30S and possibly 50S ribosomal subunits of susceptible bacteria. Doxycycline may block the dissociation of peptidyl t-RNA from ribosomes, causing RNA-dependent protein synthesis to arrest.

Metronidazole (MetroCream, MetroGel)

Metronidazole is active against various anaerobic bacteria and protozoa. It appears to be absorbed into the cells; the intermediate metabolized compounds that are formed bind DNA and inhibit protein synthesis, causing cell death.


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