Which medications in the drug class Corticosteroids are used in the treatment of Acne Keloidalis Nuchae (AKN)?

Updated: Nov 13, 2020
  • Author: Elizabeth K Satter, MD, MPH; Chief Editor: William D James, MD  more...
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Answer

Corticosteroids

These agents are used for their anti-inflammatory properties, but they must be used with caution because they have local and systemic adverse effects. Topical corticosteroids may be used alone or in combination retinoic acid.

Triamcinolone (Kenalog-10, Kenalog-40, Aristospan)

Triamcinolone can be used topically or injected intralesionally. It decreases inflammation by suppressing the migration of PMN leukocytes and reversing capillary permeability.

Prednisone

Prednisone may decrease inflammation by reversing increased capillary permeability and suppressing PMN activity. It is used when the patient has an acute flare.

Clobetasol propionate (Temovate, Clobex, Cormax)

Clobetasol propionate is a class 1, superpotent steroid that can be applied to the skin twice daily for 2 weeks. It comes in various formulations as solutions, lotions, creams, ointments, gels, and foams. Clobetasol propionate causes vasoconstriction, inhibits mitotic activity, and stimulates the synthesis of enzymes responsible for decreasing inflammatory reactions.

Halobetasol (Ultravate)

Halobetasol inhibits the initial manifestation of the inflammatory process, as well as the subsequent sequelae, which may include angiogenesis and fibroblast proliferation.

Fluocinonide (Vanos)

Fluocinonide is a class 2, potent topical steroid. It is available in various formulations, including a solution, cream, and ointment.


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