Which medications in the drug class Antibiotics, Other are used in the treatment of Acne Keloidalis Nuchae (AKN)?

Updated: Nov 13, 2020
  • Author: Elizabeth K Satter, MD, MPH; Chief Editor: William D James, MD  more...
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Answer

Antibiotics, Other

Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of this clinical setting.

Mupirocin (Bactroban, Centany)

Mupirocin is a topical antibiotic; it inhibits bacterial growth by inhibiting RNA and protein synthesis.

Doxycycline (Doryx, Adoxa, Monodox, Vibramycin)

Doxycycline is a broad-spectrum antibiotic with excellent gram positive coverage, including most resistant staph organisms. It inhibits protein synthesis and, thus, bacterial growth by binding to 30S and possibly 50S ribosomal subunits of susceptible bacteria. Doxycycline may block dissociation of peptidyl t-RNA from ribosomes, causing RNA-dependent protein synthesis to arrest.

Rifampin (Rifadin)

Rifampin inhibits RNA synthesis in bacteria by binding to the beta-subunit of DNA-dependent RNA polymerase, which, in turn, blocks RNA transcription.


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