Which medications in the drug class Immunosuppressants are used in the treatment of Rosacea?

Updated: Aug 14, 2018
  • Author: Agnieszka Kupiec Banasikowska, MD; Chief Editor: William D James, MD  more...
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Answer

Immunosuppressants

These agents inhibit immune reactions resulting from diverse stimuli.

Tacrolimus ointment (Protopic)

Tacrolimus ointment reduces itching and inflammation by suppressing the release of cytokines from T cells. It also inhibits transcription of genes encoding IL-3, IL-4, IL-5, GM-CSF, and TNF-alpha, all of which are involved in the early stages of T-cell activation. Additionally, it may inhibit the release of preformed mediators from skin mast cells and basophils, and may down-regulate the expression of FCeRI on Langerhans cells. Tacrolimus ointment can be used in patients as young as 2 years. Drugs of this class are more expensive than topical corticosteroids. It is available as ointment in concentrations of 0.03% and 0.1% and is indicated only after other treatment options have failed.


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