What is the role of ivermectin (Soolantra) in the treatment of rosacea?

Updated: Jun 03, 2020
  • Author: Agnieszka Kupiec Banasikowska, MD; Chief Editor: William D James, MD  more...
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Topical ivermectin (Soolantra) has been approved by the FDA for treatment of the inflammatory lesions of rosacea. Stein et al reported in 2014 that ivermectin 1% cream was safe and effective for the treatment of inflammatory lesions from papulopustular rosacea, based on 2 randomized, controlled, double-blind, identically designed studies of ivermectin 1% cream versus vehicle applied once daily for 12 weeks. [25] Several case reports have described successful rosacea treatment with topical acaricidal agents, [26, 27, 28] most recently in a 12-year-old girl with D folliculorum –associated rosacea who had complete resolution of her symptoms following a single dose of oral ivermectin. [29] Phase 3 randomized clinical trials to study effects of topical ivermectin 1% cream on rosacea have been completed; these trials compared the safety and efficacy of 1% ivermectin with 0.75% metronidazole cream and 15% azelaic acid gel. [30, 31, 32]

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