Which medications in the drug class Immunomodulators are used in the treatment of Perioral Dermatitis?

Updated: Aug 16, 2019
  • Author: Hans J Kammler, MD, PhD; Chief Editor: William D James, MD  more...
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Answer

Immunomodulators

Pimecrolimus cream controls atopic dermatitis.

Pimecrolimus (Elidel)

Pimecrolimus is the first nonsteroid cream approved in the United States for mild-to-moderate atopic dermatitis. It is derived from ascomycin, a natural substance produced by the fungus Streptomyces hygroscopicus var ascomyceticus. Pimecrolimus selectively inhibits the production and release of inflammatory cytokines from activated T-cells by binding to cytosolic immunophilin receptor macrophilin-12. The resulting complex inhibits phosphatase calcineurin, thus blocking T-cell activation and cytokine release. Cutaneous atrophy is not observed in clinical trials, a potential advantage over topical corticosteroids.


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