Which medications in the drug class Retinoid-Like Agents are used in the treatment of Perioral Dermatitis?

Updated: Aug 16, 2019
  • Author: Hans J Kammler, MD, PhD; Chief Editor: William D James, MD  more...
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Answer

Retinoid-Like Agents

These agents reduce the size of the sebaceous glands, decrease sebum secretion, and inhibit keratinization.

Isotretinoin (Amnesteem, Claravis, Sotret)

Isotretinoin is an oral agent used to treat serious dermatologic conditions. It is a synthetic 13-cis isomer of naturally occurring tretinoin (trans -retinoic acid). Both agents are structurally related to vitamin A. Isotretinoin decreases sebaceous gland size and sebum production. It may inhibit sebaceous gland differentiation and abnormal keratinization. Isotretinoin is indicated for long-standing and refractory forms of perioral dermatitis. Because of adverse effects, therapy should be prescribed only by a physician familiar with this drug (ie, dermatologist).

A US Food and Drug Administration–mandated registry is now in place for all individuals prescribing, dispensing, or taking isotretinoin. For more information on this registry, see iPLEDGE. This registry aims to further decrease the risk of pregnancy and other unwanted and potentially dangerous adverse effects during a course of isotretinoin therapy.


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