Which topical therapies are effective for the treatment of perioral dermatitis (POD)?

Updated: Aug 16, 2019
  • Author: Hans J Kammler, MD, PhD; Chief Editor: William D James, MD  more...
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Answer

In mild cases, as well as in most children and pregnant women, individualized topical therapy is generally recommended. Antimicrobial agents (eg, metronidazole [6, 17, 18, 19] and erythromycin) are administered in a nongreasy base (eg, gel, lotion, cream). Pimecrolimus cream significantly reduced the Perioral Dermatitis Severity Index [20] (PODSI) compared with vehicle in a randomized, double-blind study in adults. [21] Pimecrolimus cream seems to be most effective in steroid-induced perioral dermatitis. [22] Topical antiacne medications such as adapalene [23] and azelaic acid [24, 25] have been used in open studies. Ointments should be avoided.


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