What is neutrophilic eccrine hidradenitis (NEH)?

Updated: Jun 22, 2021
  • Author: Joseph C Pierson, MD; Chief Editor: Dirk M Elston, MD  more...
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Neutrophilic eccrine hidradenitis (NEH) was initially described in acute myelogenous leukemia (AML) patients undergoing chemotherapy. [1, 2] Neutrophilic eccrine hidradenitis has since been reported in persons with various neoplastic and nonneoplastic conditions and in otherwise healthy individuals; however, most documented cases have continued to be observed in the setting of AML, usually in association with chemotherapy; the name toxic erythema of chemotherapy has been proposed. [3] It has also been associated with other drugs, including pegfilgrastim, the antiplatelet agent ticagrelor, and infliximab, as well as various infections. [4, 5, 6, 7, 8]

Patients with this uncommon, self-limited condition usually present with fever and nonspecific cutaneous lesions. Children may develop a palmoplantar variant of neutrophilic eccrine hidradenitis unassociated with underlying disease. [9] Plantar neutrophilic hidradenitis is associated with Pseudomonas overgrowth in sweaty or wet sneakers and has also been dubbed Pseudomonas hotfoot. A skin biopsy specimen demonstrating characteristic pathologic changes of the eccrine glands is required to confirm a diagnosis of neutrophilic eccrine hidradenitis.

Also see the Medscape articles Acute Myelogenous Leukemia and Chronic Myelogenous Leukemia.

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