What are the signs and symptoms of follicular papulopustular eruption caused by EGFR inhibitor therapy?

Updated: Oct 08, 2020
  • Author: Elizabeth K Satter, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Answer

The follicular papulopustular eruption secondary to epidermal growth factor receptor inhibitors usually presents within the first 2-weeks of initiation of therapy. Typically it occurs on the face, scalp, chest, and upper back and is often associated with pruritus, pain, and desquamation. The eruption is dose-dependent and peaks after 3-4 weeks of therapy. Although, the eruption can negatively affect the quality of life of some patients, some authors believe the acneiform eruption also seems to correlate with a good response to therapy. [9, 10]


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