What is the role of simvastatin/ezetimibe in the treatment of alopecia areata?

Updated: Aug 06, 2020
  • Author: Chantal Bolduc, MD, FRCPC; Chief Editor: Dirk M Elston, MD  more...
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Answer

A prospective, open-label pilot study using simvastatin/ezetimibe showed some response that seemed to be maintained while taking the drug, but most relapsed once it was discontinued. [63] Only 19 of 29 patients completed the study. One patient was noncompliant, but reasons for lost to follow-up or withdrawal are not specified for the other patients. A 2019 retrospective study of 25 patients showed that 6 patients had a moderate or complete response to treatment, but 63% relapsed while still under treatment. [64]


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