What is the efficacy of methotrexate for the treatment of alopecia areata?

Updated: Jun 07, 2018
  • Author: Chantal Bolduc, MD, FRCPC; Chief Editor: Dirk M Elston, MD  more...
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Answer

Joly [43] reported 22 patients with long-standing, severe alopecia areata who responded well to methotrexate, with or without systemic corticosteroids. Although the results from that study are surprisingly good, a more standardized study involving more patients is needed because other dermatologists have not had such good efficacy with methotrexate. A 2016 study suggests that long-term maintenance treatment is usually required to maintain hair growth. [44] Risks versus benefits must be carefully weighed.


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