What is the efficacy of topical cyclosporin A (CsA) in the treatment of alopecia areata?

Updated: Jun 07, 2018
  • Author: Chantal Bolduc, MD, FRCPC; Chief Editor: Dirk M Elston, MD  more...
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Answer

Topical cyclosporine has not proven to be effective in severe alopecia areata because no patient (0 of 10) showed benefit with application of a 10% cyclosporin A (CsA) solution twice per day for 12 months.

Another study of 14 patients using a 5% solution of cyclosporine twice per day for 4-6 months reported vellus growth in 3 of 14 patients and normal hair growth in 3 patients with patchy alopecia areata. No regrowth was seen in 8 of the patients.

Neither study showed systemic absorption of CsA, and routine blood examination showed only a transient increase of hepatic enzymes in 1 patient.


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