What is the efficacy of diphencyprone (DPCP) for the treatment of alopecia areata?

Updated: Jun 07, 2018
  • Author: Chantal Bolduc, MD, FRCPC; Chief Editor: Dirk M Elston, MD  more...
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Answer

In a report of a 5-year experience with the use of DPCP, 97 subjects received continued therapy with DPCP. A response rate of greater than 75% was seen in 15% at 6 months, 49% at 12 months, 53% at 18 months, and 56% at 24 months. The only variable that seemed to affect response to treatment was the baseline extent of the alopecia areata. A greater than 75% response rate was seen in 100% of patients with 25-49% hair loss at baseline, 77% of those with 50-74% loss at baseline, 54% of those with 75-99% loss at baseline, 50% of alopecia totalis patients, and 41% of alopecia universalis patients demonstrated a response. Maintenance treatment (once every 1-4 wk) appeared to reduce the risk of relapse (>25% hair loss). Only 18% of patients experienced relapse on maintenance therapy, compared with 57% in those who discontinued treatment. [29]


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