What is the efficacy of topical immunotherapy for the treatment of alopecia areata?

Updated: Jun 07, 2018
  • Author: Chantal Bolduc, MD, FRCPC; Chief Editor: Dirk M Elston, MD  more...
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Answer

Cosmetically acceptable regrowth with topical immunotherapy rates in patients with severe alopecia areata (>50% involvement) varies from 22-68%. Most studies have a success rate of 30-50%. Wiseman et al [28] retrospectively reported the results of a large cohort of 148 consecutive patients treated with DPCP.

Their analysis showed that the cumulative patient response at 32 months was 77.9%. The response rate varied with the extent of the alopecia. Cosmetically acceptable regrowth was seen in 17.4% of patients with alopecia totalis or alopecia universalis, 60.3% in patients with 75-99% hair loss, 88.1% in patients with 50-74% hair loss, and 100% regrowth in those with 25-49% hair loss.


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