Which medications in the drug class Aldosterone Antagonists, Selective are used in the treatment of Acne Vulgaris?

Updated: Mar 26, 2019
  • Author: Jaggi Rao, MD, FRCPC; Chief Editor: William D James, MD  more...
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Aldosterone Antagonists, Selective

Aldosterone antagonists may reduce free testosterone levels and compete with androgens binding at the sebaceous gland.

Spironolactone (Aldactone)

Spironolactone is an aldosterone antagonist that competes with testosterone and dihydrotestosterone binding at the receptor in the sebaceous gland. It also reduces free testosterone levels as more blood is bound by an increased quantity of SHBG. To treat acne in women, 25-200 mg once daily may be administered.

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