What is the pathogenesis of acne vulgaris?

Updated: Mar 26, 2019
  • Author: Jaggi Rao, MD, FRCPC; Chief Editor: William D James, MD  more...
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Answer

The pathogenesis of acne vulgaris is multifactorial. The key factor is genetics. [3] Acne develops as a result of an interplay of the following four factors [2] :

  • Release of inflammatory mediators into the skin

  • Follicular hyperkeratinization with subsequent plugging of the follicle

  • Cutibacterium acnes (formerly Propionibacterium acnes) follicular colonization

  • Excess sebum production


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