Which physical findings are characteristic of lentigo simplex?

Updated: Feb 23, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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The physical appearance and morphology of lentigines depend on the type of lesion.

Lentigo simplex

Lentigo simplex (eg, simple lentigo, juvenile lentigo) is the most common form of lentigo. Lentigo simplex is not induced by sun exposure, and it is not associated with systemic disease. Clinically, the lesions are round or oval asymptomatic macules that are 3-15 mm in diameter. Their margins can be either jagged or smooth. Pigmentation is evenly distributed, with a color ranging from brown to black. The lesions are few in number and may occur anywhere on the skin or mucous membranes. The lesions usually appear first in early childhood, but they can also be present at birth or develop later.

Multiple dysplastic nevi and lentigines were reduced in number in a patient with familial gastrointestinal stromal tumors syndrome after treatment with imatinib mesylate. [19] The effect of effect of imatinib on pigmentation is not well understood.

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