What causes lentigo?

Updated: Feb 23, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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The cause of lentigo formation depends on the type of lesion, as follows:

  • The cause of lentigo simplex is unknown. Case reports have described simple lentigines developing in children after use of topical tacrolimus for atopic dermatitis. [9]

  • Solar lentigo and ink-spot lentigo are associated with sun exposure in fair-skinned people.

  • PUVA lentigines [10, 11, 12] are associated with PUVA therapy in patients with psoriasis.

  • Radiation lentigo is caused by local high-dose irradiation. [13]

  • Genetic factors may be involved in other forms of lentigines, including XP, LEOPARD syndrome, Peutz-Jeghers syndrome, and inherited patterned lentiginosis.

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