Which medications in the drug class Immunomodulatory agents are used in the treatment of Systemic Sclerosis?

Updated: Apr 16, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Answer

Immunomodulatory agents

These agents are used to stop disease progression. They act on the host's immune system; they suppress the immune system to prevent fibrosis.

Prednisone (Deltasone, Meticorten, Orasone, Sterapred)

Prednisone is an immunosuppressant used for the treatment of autoimmune disorders; it may decrease inflammation by reversing increased capillary permeability and suppressing PMN activity. Prednisone stabilizes lysosomal membranes and suppresses lymphocytes and antibody production.

Methotrexate (Rheumatrex)

Methotrexate is an antimetabolite that inhibits dihydrofolate reductase, thereby hindering DNA synthesis and cell reproduction. A satisfactory response is observed 3-6 weeks after administration. Adjust the dose gradually to achieve a satisfactory response.

Chlorambucil (Leukeran, Leukeran)

Chlorambucil alkylates and cross-links strands of DNA, inhibiting DNA replication and RNA transcription.

Cyclosporine (Neoral, Sandimmune)

Cyclosporine is helpful in a variety of skin disorders.

Tacrolimus (Prograf)

Tacrolimus suppresses humoral (T-lymphocyte) immunity.

Cyclophosphamide (Neosar, Cytoxan)

Cyclophosphamide is chemically related to nitrogen mustards. As an alkylating agent, the mechanism of action of the active metabolites may involve DNA cross-linking, which may interfere with the growth of healthy and neoplastic cells.


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