Which medications in the drug class Antifibrotic agents are used in the treatment of Systemic Sclerosis?

Updated: Nov 11, 2020
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Antifibrotic agents

These agents are used to decrease fibrosis by interference with collagen metabolism.

Penicillamine (Cuprimine, Cuprimine, Depen)

Penicillamine is a metal chelation agent used to treat arsenic poisoning. It forms soluble complexes with metals excreted in urine.


Colchicine decreases leukocyte motility and phagocytosis in inflammatory responses.

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