What is the role of drug treatment for systemic sclerosis (SSc)?

Updated: Apr 16, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Attaining a patient-acceptable symptom state in scleroderma can be challenging. [66] Treatment regimens have enormous diversity. Currently, no standard and effective therapy is available for skin sclerosis. Agents effective in other rheumatic diseases are less so in systemic sclerosis. [67] Raynaud phenomenon often responds to calcium channel blockers, and scleroderma kidney disease may respond to angiotensin-converting enzyme and angiotensin II inhibitors. The treatment depends on the presentation of systemic sclerosis. The efficacy and safety of lidocaine in treating scleroderma has been questions, with an analysis showing a lack of efficacy. [68]

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