What is the role of lab studies in the diagnosis of systemic sclerosis (SSc)?

Updated: Apr 16, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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The following findings may be found with laboratory studies:

  • Increased erythrocyte sedimentation rate

  • Thrombocytopenia

  • Hypergammaglobulinemia

  • Microangiopathic hemolytic anemia

  • Increased creatine phosphokinase levels in patients with muscle involvement

  • Increased urea and creatinine levels in patients with kidney involvement

  • C-reactive protein: The nonspecific inflammatory marker C-reactive protein was found elevated in about one quarter of patients with systemic sclerosis, especially early disease, in whom it correlated with disease activity, severity, poor pulmonary function, and shorter survival. [34]

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