How do the medical signs and symptoms of systemic sclerosis (SSc) correlate to outcomes?

Updated: Apr 16, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Medical signs and symptoms associated with disability, pain, and psychosocial adjustment in systemic sclerosis were assessed. [18] In one study, 114 patients underwent examination, including a determination of skin thickening. Signs and symptoms were a significant correlate of all outcomes. Patient-reported dependent edema significantly correlated with all outcomes. For disability, significant correlates were (1) physician-determined joint tenderness and number of tender points and (2) patient-reported joint pain with motion, joint contracture, extremity ulcers other than digital, and dyspnea. Avascular areas in capillaroscopy, elevation of Health Assessment Questionnaire-Disability Index (HAQ-DI) score, and anti-Scl-70 antibodies were independent factors associated with digital ulcers in a survey of 70 Brazilian systemic sclerosis patients. [19]

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