Which medications in the drug class Calcium channel blockers are used in the treatment of CREST Syndrome?

Updated: Oct 05, 2020
  • Author: Jeanie C Yoon, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Calcium channel blockers

These agents are used as part of therapy for Raynaud phenomenon.

Nicardipine (Cardene)

Nicardipine is used for its vasodilatation and possible antiplatelet effects. Start with the lowest dose available. Extended-dose preparations and agents with fewer negative inotropic effects are preferred.

Nifedipine (Procardia)

Nifedipine relaxes coronary smooth muscle and produces coronary vasodilation, which, in turn, improves myocardial oxygen delivery; adverse reactions occur predominantly with short-acting formulations and include peripheral edema, headache, dizziness, and tachycardia; calcium channel blockers may worsen gastroesophageal reflux; SR formulations are associated with fewer adverse effects.


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