Which medications in the drug class Phosphodiesterase enzyme inhibitors are used in the treatment of CREST Syndrome?

Updated: Oct 05, 2020
  • Author: Jeanie C Yoon, MD; Chief Editor: Dirk M Elston, MD  more...
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Phosphodiesterase enzyme inhibitors

This class is for the treatment of Raynaud phenomenon.

Cilostazol (Pletal)

Cilostazol affects vascular beds and cardiovascular function. It may improve blood flow by altering the rheology of red blood cells. It produces nonhomogenous dilation of vascular beds, with more dilation in femoral beds than in vertebral, carotid, or superior mesenteric arteries.

Cilostazol and its metabolites are inhibitors of phosphodiesterase III and, as a result, cyclic AMP is increased, which leads to inhibition of platelet aggregation and vasodilation.

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