Which medications in the drug class Antihypertensive agents are used in the treatment of CREST Syndrome?

Updated: Oct 05, 2020
  • Author: Jeanie C Yoon, MD; Chief Editor: Dirk M Elston, MD  more...
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Antihypertensive agents

This class is for Raynaud phenomenon.

Losartan (Cozaar)

Losartan is a nonpeptide angiotensin II receptor antagonist that blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II. It may induce a more complete inhibition of the renin-angiotensin system than ACE inhibitors. It does not affect the response to bradykinin and is less likely to be associated with cough and angioedema. It is used for patients unable to tolerate ACE inhibitors. Losartan is less effective in patients with scleroderma than in those with primary Raynaud phenomenon. It may modify some serum markers of vascular damage and possibly modulate some of the underlying tissue damage in scleroderma.

Nitroglycerin topical (Nitro-Bid, Nitro-Dur, Nitrogard)

Nitroglycerin relaxes smooth muscle all over the body, including those of the LES and esophageal body.

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