What are complications of CREST syndrome?

Updated: Oct 05, 2020
  • Author: Jeanie C Yoon, MD; Chief Editor: Dirk M Elston, MD  more...
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Limited disease is associated with better survival rates than diffuse disease (50% at 12 y compared to 15% for diffuse scleroderma).

Renal involvement is responsible for half the scleroderma-related deaths in patients with widespread skin changes, while patients with sclerodactyly alone do not tend to develop any renal disease.

Mortality in patients with limited skin involvement is a result of cardiac, pulmonary, and GI causes.

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