Which lab studies are performed in the workup of pemphigus vulgaris?

Updated: Jun 14, 2018
  • Author: Bassam Zeina, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Laboratory studies include the following:

  • Histopathology: Demonstrates an intradermal blister; the earliest changes consist of intercellular edema with loss of intercellular attachments in the basal layer

  • Direct immunofluorescence (DIF): On normal-appearing perilesional skin [7] ; demonstrates in vivo deposits of antibodies and other immunoreactants, such as complement [8]

  • Indirect immunofluorescence (IDIF): If DIF results are positive; circulating intercellular antibodies are detected using IDIF in 80-90% of patients with pemphigus vulgaris [9]

See Workup for more detail.


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