Which medications in the drug class Anti-inflammatory agents are used in the treatment of Bullous Pemphigoid?

Updated: Oct 14, 2020
  • Author: Lawrence S Chan, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Anti-inflammatory agents

These agents inhibit the inflammatory process by inhibiting specific cytokine production and vascular permeability. They may also stabilize granulocyte membranes and prevent release of key enzymes.

Prednisone (Deltasone)

Prednisone may decrease inflammation by reversing increased capillary permeability and suppressing PMN activity. When taken orally, it is used alone or in conjunction with other immunosuppressive agents for treating bullous pemphigoid.

Tetracycline (Sumycin)

Although an antibiotic, tetracycline has proven effective in some cases of bullous pemphigoid either alone or in conjunction with niacinamide (2 g/d). Efficacy may be due to anti-inflammatory properties.

Clobetasol (Temovate)

Clobetasol is a class I superpotent topical steroid; it suppresses mitosis and increases the synthesis of proteins that decrease inflammation and cause vasoconstriction. It is useful in treating localized bullous pemphigoid or in conjunction with low-dose systemic corticosteroids to treat the generalized disease.


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