What are possible complications of bullous pemphigoid (BP)?

Updated: Oct 14, 2020
  • Author: Lawrence S Chan, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Secondary infection may occur because of the presence of multiple erosions and immunosuppressants used to control the disease. These infections may be either systemic or localized to the skin. Cutaneous infection increases the risk of scarring and delays wound healing.

Malignancies due to immunosuppressants have been reported. Case-control series in patients with bullous pemphigoid have failed to detect an increased incidence of malignancy in patients with bullous pemphigoid when compared with age- and sex-matched controls

Bone marrow suppression may occur in patients receiving immunosuppressants.

Growth restriction may occur in children receiving systemic corticosteroids and immunosuppressants. Adrenal insufficiency may occur following prolonged use of glucocorticoids. Osteoporosis and bone fractures may result following the use of systemic corticosteroids. Associated neurodegenerative disease may be antibody-mediated. [65]

There may be a higher incidence of squamous carcinoma and lymphoma in patients with pemphigoid. [66]


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