Which history findings suggest bullous pemphigoid (BP)?

Updated: Oct 14, 2020
  • Author: Lawrence S Chan, MD; Chief Editor: Dirk M Elston, MD  more...
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The onset of bullous pemphigoid may be either subacute or acute, with widespread, tense blisters. Significant pruritus is frequently present and may be the only manifestation of the disease, especially in older patients. [56] In some patients, the blisters arise after persistent urticarial lesions.

Bullous pemphigoid has been reported following several nonbullous, chronic, inflammatory skin diseases, such as lichen planus and psoriasis.

Bullous pemphigoid has been reported to be precipitated by ultraviolet irradiation, x-ray therapy, and exposure to some drugs.

Drugs associated with bullous pemphigoid include furosemide, ibuprofen and other nonsteroidal anti-inflammatory agents, captopril, penicillamine, and antibiotics.

Bullous pemphigoid has been reported to develop shortly after vaccination, particularly in children. [57]

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