What are the possible sequelae of bullous pemphigoid (BP)?

Updated: Oct 14, 2020
  • Author: Lawrence S Chan, MD; Chief Editor: Dirk M Elston, MD  more...
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Bullous pemphigoid involves the mucosa in 10-25% of patients. Patients who are affected may have limited oral intake secondary to dysphagia. Erosions secondary to rupture of the blisters may be painful and may limit patients' daily living activities. Blistering on the palms and the soles can severely interfere with patients' daily functions.

Bullous pemphigoid lesions typically heal without scarring or milia formation. In a survey of patients conducted in a Midwest United States university medical center, no difference was noted in expected mortality in bullous pemphigoid 223 patients compared with the general population. [54] In a population-based cohort study in the United Kingdom, however, the risk of death for bullous pemphigoid patients was found to be twice as great as that for controls. [43] Furthermore, a Swiss prospective study confirmed a high-case fatality rate, with increased 1-year mortality compared with the expected mortality rate for age-adjusted and sex-adjusted general population. [55]

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