What is the prognosis of bullous pemphigoid (BP)?

Updated: Oct 14, 2020
  • Author: Lawrence S Chan, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Most patients affected with bullous pemphigoid require therapy for 6-60 months, after which many patients experience long-term remission of the disease. However, some patients have long-standing disease requiring treatment for years. Most mortality associated with bullous pemphigoid occurs secondary to the effects of the medications. Data suggest that high serum levels of IgG1 and IgG4 targeting the noncollagenous 16A domain of BP180 correlate with more serious disease and a worse prognosis. [45] Age and the presence of circulating antibodies are also associated with poor outcome. [46]


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