What is the role of immunofluorescence in the workup of bullous disease of diabetes (bullosis diabeticorum)?

Updated: Dec 06, 2019
  • Author: Sofia Junaid Syed, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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No primary immunologic abnormality is noted in bullous disease of diabetes. Although nonspecific capillary-associated immunoglobulin M and C3 and IgG deposition in superficial capillary basement membrane have been reported, albeit rarely, [11, 16] immunofluorescence findings have not been consistently reproduced by others, and direct immunofluorescence findings are usually negative. [22] However, immunofluorescence studies may be required to exclude clinically similar conditions (eg, bullous pemphigoid, epidermolysis bullosa acquisita, porphyrias) that typically show deposition of C3 and IgG along the basement membrane zone.

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