Which clinical history findings are characteristic of bullous disease of diabetes (bullosis diabeticorum)?

Updated: Dec 06, 2019
  • Author: Sofia Junaid Syed, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Bullous disease of diabetes (bullosis diabeticorum) blisters occur spontaneously and abruptly, often overnight, and usually without known antecedent trauma. Most frequently, it is observed as a unilateral lesion involving the foot or leg, although bilateral lesions as well as multiple lesions have been reported; other regions such as the trunk, arms, and hands can be affected. [2] The tense blisters are usually large and asymmetrical in shape and filled with clear fluids, but hemorrhagic blisters have been reported. [21] Blisters tend to be asymptomatic, although mild discomfort or burning has been described at onset. [2] Bullous disease of diabetes blisters heal spontaneously within 2-6 weeks of onset. [1] During the healing process, the fluid leaks, leaving a darkened crust over the affected area that dissolves over time. [2]

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