What is the prevalence of bullous disease of diabetes (bullosis diabeticorum)?

Updated: Feb 04, 2019
  • Author: Maureen B Poh-Fitzpatrick, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Bullous disease of diabetes (bullosis diabeticorum) is rare, with only about 100 cases reported. In the United States, bullous disease of diabetes has been reported to occur in approximately 0.5% of diabetic patients, although its frequency may actually be higher due to underreporting of blistering. Patients with uncomplicated or newly diagnosed disease, including type 2 diabetes, may also be affected.

The age of onset of bullous disease of diabetes typically ranges from 17 to 84 years, although a case in a 4-year old child has been reported. [15] Bullous disease is more frequent in adult men suffering from long-standing, uncontrolled diabetes with peripheral neuropathy, with a male-to-female ratio of 2:1. [1]


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