What is the prevalence of bullous disease of diabetes (bullosis diabeticorum)?

Updated: Dec 06, 2019
  • Author: Sofia Junaid Syed, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Bullous disease of diabetes (bullosis diabeticorum) is rare, with only about 100 cases reported. Incidence of the disease is around 0.16% per year. [13] In the United States, bullous disease of diabetes has been reported to occur in approximately 0.5% of diabetic patients, although its frequency may actually be higher due to underreporting of blistering. Patients with uncomplicated or newly diagnosed disease, including type 2 diabetes, may also be affected. Rarely, the disease has been reported in a prediabetes patient. [17]

The age of onset of bullous disease of diabetes typically ranges from 17 to 84 years, although a case in a 4-year old child has been reported. [18] Bullous disease is more frequent in adult men suffering from long-standing, uncontrolled diabetes with peripheral neuropathy, with a male-to-female ratio of 2:1. [1]

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