Which histologic findings are characteristic of epidermal inclusion cysts (EIC)?

Updated: Sep 17, 2020
  • Author: Linda J Fromm, MD, MA, FAAD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Epidermoid cysts are lined with stratified squamous epithelium that contains a granular layer. Laminated keratin contents are noted inside the cyst. An inflammatory response may be present in cysts that have ruptured. Older cysts may exhibit calcification. Pilomatrical differentiation may be noted, especially in patients with Gardner syndrome. [38]

Note the images below.

Cyst containing keratinous material (hematoxylin a Cyst containing keratinous material (hematoxylin and eosin, original magnification X1.6).
Higher-magnification view of the cyst wall of the Higher-magnification view of the cyst wall of the cyst in Media File 3 demonstrates a true epidermis with a granular layer and adjacent laminated keratinous material (hematoxylin and eosin, original magnification X20).

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