What is the pathogenesis of carcinoma in epidermal inclusion cysts (EIC)?

Updated: Sep 17, 2020
  • Author: Linda J Fromm, MD, MA, FAAD; Chief Editor: Dirk M Elston, MD  more...
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Answer

The manner in which carcinomas may arise within epidermoid cysts is unclear. In a series of epidermoid cysts with carcinoma, immunohistochemical results for HPV were negative, suggesting that HPV is not likely to play a role in the development in squamous cell carcinoma (SCC) in epidermoid cysts. Chronic irritation or repetitive trauma to the epithelial lining of the cyst has been suggested to play a role in malignant transformation; however, this relationship has not been established. [28]


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