Which histologic findings are characteristic of the hyperkeratotic type of seborrheic keratosis?

Updated: Oct 14, 2020
  • Author: Arthur K Balin, MD, PhD, FACP; Chief Editor: William D James, MD  more...
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Answer

Hyperkeratotic seborrheic keratoses, shown in the images below, have pronounced hyperkeratosis and papillomatosis with less acanthosis. When papillomatosis is particularly prominent, the histology resembles acrokeratosis verruciformis of Hopf. The epidermis is largely composed of squamous cells interspersed with aggregates of basaloid cells.

Hyperkeratotic type of seborrheic keratosis. Hyperkeratotic type of seborrheic keratosis.
Seborrheic keratoses projecting above the level of Seborrheic keratoses projecting above the level of the epidermis. Cysts represent sections of hyperkeratotic follicles.

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